f you’ve tried every cream under the sun but your skin still feels tired, uneven, or just not your best — you’re not alone. At One’s Clinic in Apgujeong, we often say: your skin’s software (its regenerative and metabolic systems) needs an upgrade — not just another topical patch.

In this piece, we’ll compare two increasingly popular in-office treatments in Korea:

• Rejuran Healer (a polynucleotide skin-booster treatment)

• Platelet Rich Plasma (PRP) therapy (using your own blood-derived growth factors)

We’ll dig into what they are, how they work, how they differ, and help you (and your doctor) decide which might be more appropriate for your skin and your goals.

What They Are & How They Work

Rejuran Healer

At its core, Rejuran Healer is a skin-booster injectable treatment using polynucleotides (PN) derived from salmon DNA. These PN molecules are similar to the building blocks of human DNA and are known to help repair and rejuvenate skin at a cellular level. When micro-injected into the dermis, they activate the skin’s regenerative process by stimulating fibroblasts, enhancing collagen and elastin production, improving microcirculation, and strengthening the skin barrier.

Here’s what we often see:

• Improved skin texture and elasticity (the “firmness” and bounce)

• Better hydration from within

• Smoother tone, less visible pores, fewer fine lines

• Strengthened skin barrier for long-term resilience

The treatment is typically done in a series (usually three sessions spaced about four weeks apart), followed by maintenance every 6 to 12 months. Downtime is minimal, often limited to minor swelling, tiny injection marks, and occasional bruising. In our experience at One’s Clinic, most patients start noticing subtle improvements within a few weeks, with more significant results emerging over time.

PRP (Platelet Rich Plasma)

PRP involves drawing a small amount of your own blood, centrifuging it to isolate the platelets and plasma, then injecting or microneedling it into the skin. The idea is to leverage your body’s own regenerative potential. Platelets are rich in growth factors that can stimulate tissue repair, collagen synthesis, and improved skin quality.

PRP is considered an autologous treatment, meaning it uses your own biological material, which minimizes the risk of rejection or allergic reaction. It’s increasingly used in dermatology not only for skin rejuvenation but also for hair restoration, scar improvement, and under-eye dark circles.

The results of PRP are gradual. Patients typically need multiple sessions to achieve optimal results. Improvements in skin tone, texture, and firmness often become noticeable 6 to 12 weeks after treatment. One’s Clinic frequently integrates PRP into broader skin recovery protocols, especially for patients with signs of deeper tissue damage or scarring.

What’s the Difference? Side-by-Side Comparison

Here’s a breakdown comparing the two, so you and your doctor can weigh which aligns best with your skin’s needs and expectations.

Which One Should You Choose? (and Why)

At One’s Clinic, led by Dr. Hae-in Lee and Dr. Jong-eon Song, we prioritize root-cause diagnosis. That means the choice between Rejuran and PRP isn’t just about trends or technology — it’s about your skin’s story.

Ask Yourself These Questions

1. What is my primary skin concern?

   • For dullness, minor laxity, and skin that “feels tired” despite good care, Rejuran often restores inner glow and elasticity.

   • For scars, deeper texture issues, or pigmentation, PRP may deliver more regenerative depth.

2. How sensitive is my skin?
   Rejuran is generally well-tolerated, but because it involves more injection points, it may feel more intensive. PRP is sometimes gentler on highly reactive skin since it uses your own cells.

3. Am I already managing other health issues?
   If you’re dealing with hormonal shifts, metabolic imbalance, or systemic inflammation, these may impact your skin’s ability to heal. In such cases, Rejuran’s reparative focus can be advantageous, especially when paired with supportive treatments that One’s Clinic offers to rebalance the internal terrain.

4. What are my expectations?
   Neither treatment is an overnight fix. Rejuran may show quicker surface-level improvement, while PRP might build more structural change with repeated sessions. Clear communication with your doctor about what you hope to see — and how soon — matters.

5. Am I comfortable with blood-based treatments?
   While PRP is safe, some individuals prefer non-blood-based options. In that case, Rejuran is an excellent alternative that delivers biological stimulation without blood handling.

My Recommendation (based on scenarios)

• Scenario A – A woman in her 30s with thinning skin, enlarged pores, and mild dehydration: Rejuran is likely ideal.

• Scenario B – A man in his 40s with post-acne scarring and visible sun damage: PRP would be more appropriate.

• Scenario C – A skincare-savvy patient who’s tried lasers and fillers but wants to rebuild the skin’s resilience: Start with Rejuran.

• Scenario D – Someone committed to holistic, low-allergy, natural-looking rejuvenation: PRP aligns with this ethos.

Integrating These into a Holistic Skin Strategy

At One’s Clinic, every skin protocol is designed not in isolation, but as part of a broader wellness journey. That means Rejuran or PRP isn’t just a standalone procedure. It’s supported by:

• Full diagnostics: including skin imaging, metabolic testing, hormone panels, and nutrient assessments

• Tailored lifestyle plans: addressing stress, sleep, nutrition, and skincare

• Adjunct therapies: such as microneedling, LED, IV nutrient drips, or gut-health optimization when relevant

• Aftercare strategy: focusing on sun protection, hydration, gentle actives, and rest

This multi-layered approach ensures your skin has the metabolic and cellular support it needs to regenerate efficiently — not just superficially, but deeply.

Realistic Benefits & Limitations

What You Can Expect

• Enhanced hydration and glow

• Improved texture and tone

• Fewer fine lines and more elasticity

• A stronger, more resilient skin barrier

• Gradual, natural-looking changes over time

What It Won’t Do

• Neither Rejuran nor PRP replaces the lifting effect of filler or surgery

• Results vary depending on age, lifestyle, skin condition, and health status

• Maintenance is essential; one session isn’t a long-term solution

• Results fade without sun protection, sleep, and nutrition

Conclusion: Which is Right?

If your main goal is hydration, glow, and foundational skin health with minimal risk, Rejuran Healer is a compelling option. If you’re tackling texture, scars, or prefer a more natural, autologous path, PRP is a powerful ally.

But the most important choice? Working with a clinic that doesn’t treat your skin in isolation. At One’s Clinic in Apgujeong, our work begins with diagnostics and lifestyle insight — not just injections.

If your skin feels tired, stressed, or stuck in an aging loop, it may be time for a root-cause consultation. We’ll help you determine whether Rejuran, PRP, or an integrative protocol is your best next step.

Your skin’s best years aren’t behind you. They’re waiting to be revealed.